Registration Clinical Trial Publications
- Yoshiya I, Ogawa R, Okumura F, et al. Clinical evaluation of landiolol hydrochloride (ONO-1101) on perioperative supraventricular tachyarrhythmia: a phase III, double-blind study in comparison with placebo (in Japanese). Rinsyoiyaku (J Clin Ther Med). 1997;13:4949–78
- Taenaka N, Kikawa S. The effectiveness and safety of landiolol hydrochloride, an ultra-short acting β1-blocker, in postoperative patients with supraventricular tachyarrhythmias: a multicenter, randomized, double-blind, placebocontrolled study. Am J Cardiovasc Drugs. 2013 Oct;13(5):353-64. doi: 10.1007/s40256-013-0035-2.
- Kato, K., H. Hayakawa, H. Atarashi, T. Sugimoto, H. Inoue, K. Hiejima, S. Ogawa, H. Iinuma, Y. Nakata, T. Tanabe, H. Kasanuki, and K. Hanaoka. 1997. Clinical effect of intravenous infusion of landiolol hydrochloride (ONO-1101) on paroxysmal atrial fibrillation and atrial flutter - A phase III, double-blind study in comparison with placebo., Rinsho Iyaku (J Clin Therap Med), 13: 4903(83)-24(104).
- Yoshiya I, Ogawa R, Okumura F, Shimada Y, Kuro M. Clinical Evaluation of Landiolol Hydrochloride (ONO-1101) on Perioperative Supraventricular Tachyarrhythmia in Patients with Hypertension or Cardiac Ischemia Double-blind Study in Comparison with Placebo Rinsho Iyaku (Jpn. J. Clin. Therap. Med.), Vol. 18, Special Issue No. 9 (September), 1049(37) 1076(64), 2002.
- Tanaka S, Kikuchi C, Saito N, Kasuya S. [Clinical evaluation of landiolol hydrochloride, an ultra-short acting beta blocker]. Kyobu Geka. 2008 Dec;61(13):1096-101.
Additional Publications
- Floria, M.; Oancea, A.F.; Morariu, P.C.; Burlacu, A.; Iov, D.E.; Chiriac, C.P.; Baroi, G.L.; Stafie, C.S.; Cuciureanu, M.; Scripcariu, V.; et al. An Overview of the Pharmacokinetics and Pharmacodynamics of Landiolol (an Ultra-Short Acting β1 Selective Antagonist) in Atrial Fibrillation. Pharmaceutics 2024, 16, 517.
- Zhou Zeming, Haixu Wang, Wei Wang, Jingkuo Li, Lubi Lei, Lihua Zhang, Haibo Zhang, Jiamin Liu, Xin Zheng, In hospital use of beta blockers for critically ill patients with acute heart failure: Whether and when to initiate, Journal of Clinical Anesthesia, Volume 103, 2025.
- McChesney, Chris MD1; Orozco, Nicolas MD2; Fiorini, Kyle MD3; Wong, Michelle Yee Suet MSc4; Slessarev, Marat MD, PhD4; Prager, Ross MD4; Kao, Raymond MD, MPH4; Leligdowicz, Aleksandra MD, PhD4,5; Sharif, Sameer MD, MSc6,7,8; Lewis, Kimberley MD, MSc7,8; Rochwerg, Bram MD, MSc7,8; Honarmand, Kimia MD, PhD9; Ball, Ian M. MD, MSc4; Arntfield, Robert MD4; Houlton, Rachael MD, PhD4; VanNynatten, Logan MD4; Basmaji, John MD4. Impact of Short-Acting Beta Blockers on the Outcomes of Patients With Septic Shock: A Systematic Review and Meta-Analysis. Critical Care Medicine 53(5):p e1125-e1139, May 2025. | DOI: 10.1097/CCM.0000000000006604.
- Caspersen, E., Guinot, PG., Rozec, B. et al. Comparison of landiolol and amiodarone for the treatment of new-onset atrial fibrillation after cardiac surgery (FAAC) trial: study protocol for a randomized controlled trial. Trials 24, 353 (2023).
- Koukoulitsios G, Tsikritsaki K, Magklaras G, Koutivas AM, Kalogeromitros A, Papaioannou V. Comparison of Landiolol and Esmolol on Haemodynamic Responses During Weaning of Intensive Care Unit Patients with Reduced Ejection Fraction after Vascular Surgery. Card Fail Rev. 2025 May 21;11:e13. doi: 10.15420/cfr.2024.18. PMID: 40458288; PMCID: PMC12127960.